Targeting VEGF or hypoxia-inducible factor ( HIF-1 ) can help normalize the tumor blood vessels, promote drug delivery, improve tumor hypoxia and the immunosuppressive microenvironment 8 , and ultimately prevent or reverse drug resistance in breast cancer
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In this scenario, a deeper understanding of the tissue specificity effects and the molecular mechanisms of PPAR- is mandatory to develop novel and safer therapies
Iizuka K, Takao K, Kato T, Horikawa Y, Takeda J